Prospective studies have shown that higher circulating concentra-
tions of insulin-like growth factor 1 (IGF-1), insulin-like growth
factor 2 (IGF-2), and insulin-like growth factor binding protein-3
(IGFBP-3) are associated with an increased risk of prostate cancer,
colorectal cancer, and premenopausal breast, and ovarian cancer
(Lukanova et al, 2002; Renehan et al, 2004). Aetiological
importance has been attributed to these associations, and it has
been suggested that they may be of value in screening for these
cancers.
We here report results on measurements of IGF-1, IGF-2, and
IGFBP-3 from the British United Provident Association (BUPA)
prospective study, based on 1051 new cases of cancer at 14
different cancer sites, and we combine the results on prostate,
colorectal, and lung cancer with those from published studies in a
meta-analysis.
Kanser riskini artırdığını söyleyen birçok makaleden biri. Özellikle meme, kolorektal, akciğer ve prostat.
Bu da makalenin doisi.
doi:10.1038/sj.bjc.6603200
